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Hisham ibn al-Mughirah was from the Banu Makhzum Sub-clan of the Quraish Tribe and was also one of Muhammads contemporary.
He was the son of Mughirah ibn Abd-Allah, one of the Leaders of Quraish. His brother was Walid ibn al-Mughira, he was the uncle of the famous Muslim general Khalid ibn al-Walid.
Exclusively in Shiite sources only, (compiled after Sunni Sources which shows the futility of the slander) he "had" a relation with Layla bint Harmalah, the mother of Amr ibn al-A'as
It is unclear whether he became Muslim.
- Non-Muslim interactants with Muslims during Prophet Muhammad's Peace be upon him's era